If you would like a brief introduction using the gui, you can watch a demonstration on statas youtube channel. I would say that revman is more straightforward to use. Metaanalysis of proportions is a tool that can calculate an overall proportion from studies reporting a single proportion. This routine provides procedures for pooling proportions in a metaanalysis of. This module should be installed from within stata by typing ssc install metaprop. Metaanalysis is a method to obtain a weighted average of results from various studies. Acute symptoms associated with salmonellosis include diarrhoea. In the second metaanalysis, the pooled percentage of cured women. The pooled proportion with 95% ci is given both for the fixed effects model and the random effects model. I have a question regarding metaanalysis on pooled proportions e. Using metaprop is not a problem, but i want to add two additional analyses. Metaanalysis of proportions hi, im interested in performing a metaanalysis of a proportionrate for example, id like to come up with an pooled estimate of the casefatality rate. Beyond this metaanalysis function, logistic regression can be used to compare pooled proportions. Consult with a statistician if you are considering a random effects logistic model.
We discuss the logit and double arcsine transformations to stabilise the variance. Meta prop uses an exact binomial method to estimate the included studies proportions of interest and their standard errors along with 95% confidence intervals. Just as you mentioned, the ma of proportions is a little different than other types of metaanalysis it includes studies that do not use controls. To install the datasets that were used in the metaanalysis in stata, type. There is an option for metaanalysis of proportions, while including all. I am performing a metaanalysis study of proportions in stata using the metaprop command. A new stata command, mvmeta, performs maximum likelihood, restricted maximum likelihood, or methodofmoments estimation of randomeffects multivariate metaanalysis models. We selected 3 illustrative published metaanalyses that demonstrated a range of proportions of zero total event trials among all trials with outcomes data, treatment effects, and heterogeneity 15. Incidence of ceramic fracture in contemporary ceramicon. In stata you can use metaan ssc install metaan and look at the help file help metaan. Stata module for fixed and random effects metaanalysis. One way is to use the freemantukey arcsin transform to stabilize variances. Stata now offers the new suite of commands, meta, to perform metaanalysis. Hi, i have recently conducted a metaanalysis using state.
Of those who developed any metastases during followup. As of stata 16, stata has an official suite of metaanalysis commands. Borenstein m, hedges lv, higgins jpt, rothstein hr 2009 introduction to metaanalysis. My data includes 10 studies for which i have the variables. See statas full list of official metaanalysis features stata users have also developed numerous excellent commands for performing metaanalyses. I have been recearching the available literature for some time now and i am still unsure if i. These studies usually come from a design in which two dichotomous responses are made on each subject or subject pair. Statas data management features give you complete control. This manual will continue to be revised to reflect changes in the program. Let n be the nominator and n the denominator for the proportion. Nontyphoidal salmonella is an important foodborne pathogen, with an estimated 938 million cases and about 155 000 deaths globally per year. In our study, the proportion p was calculated as the number of hips developing ceramic fracture divided by the total number of thas n.
Either binary event or continuous data from two groups may be combined using the metan command. Metaanalysis of hazard ratios statistical software. Bringing evidencebased decisionmaking to new heights. Metaanalysis of the proportion of women with ascus or a borderline pap smear that have a positive. In this article we present methods for the metaanalysis of prevalence. Contribute to vnyagametaprop development by creating an account on github.
The results of each study may be summarized as counts in a 2by2 table. Common sources of infection include contaminated food, such as meat, eggs and produce 2, 3 and via the faecaloral route after contact with infected animals. You enter the number of subjects responding with the study outcome and the total number of subjects studied. This collection of articles from the stata journal and stata technical bulletin will be indispensable to researchers who wish to conduct metaanalyses using stata and learn about the. The outcome of interest in each study is represented by a proportion percentage.
Metaanalysis of proportions introduction this module performs a metaanalysis of a set of twogroup, binaryevent studies. There is a specialized softwarebfor performing meta analysis i saw a lot of ads, but i have not tried it yet 12. I need to do metaanalysis of these proportions in stata. Spss and stata may also have macros for meta analysis, but we dont typically use these software. Stata is a complete, integrated software package that provides all your data science needsdata manipulation, visualization, statistics, and reproducible reporting. As of stata 16, stata has an official suite of meta analysis commands. Metaanalyses have become an essential tool in synthesizing evidence on clinical and epidemiological questions derived from a multitude of similar studies assessing the particular issue. Most older papers and many current papers do not report effect sizes. Metaprop meta analysis, variance of the synthesized. See stata s full list of official meta analysis features stata users have also developed numerous excellent commands for performing meta analyses. This site uses cookies to store information on your computer.
Jasp is a free, opensource program used to perform statistical analysis tests by using r packages. These routines provide facilities to conduct metaanalyses of data from more than one study and to graph the results. Stata is a complete, integrated statistical software package that provides everything you need for data science. Metaprop is a statistical program implemented to perform meta analyses of proportions in stata. Dersimonian r, laird n 1986 metaanalysis in clinical trials. Metaanalysis allows researchers to combine the results of several studies into a unified analysis that provides an overall estimate of the effect of interest. How to conduct a metaanalysis of proportions in r youtube. It is a userfriendly way of conducting stats without having to deal with the r code itself.
I need to do meta analysis of these proportions in stata. Metaanalysis of prevalence journal of epidemiology. Appropriate and accessible statistical software is needed to produce the summary statistic of interest. Metaprop is a statistical program implemented to perform metaanalyses of proportions in stata. Stata 16 introduces a new suite of commands for performing metaanalysis. Stata module to perform fixed and random effects meta analysis of proportions, statistical software components s457781, boston college department of economics, revised 15 apr 2020. Bero l, montgomery p, robinson k, pigott t, krause k. How metaanalysis of proportions is performed in stata. The program lists the proportions expressed as a percentage, with their 95% ci, found in the individual studies included in the metaanalysis. Has anyone used these packages to create a forest plot of proportions where the proportion and 95%ci displayed for each study is a simple proportion with. To conduct a meta analysis in jasp, be sure to check our their guide. Metaanalysis of proportions introduction this module performs a meta analysis of a set of twogroup, binaryevent studies. The results of the different studies, with 95% ci, and the pooled proportions with 95% ci are shown in a forest plot.
Upgrades to the program and manual will be available on our download site. It will also be expanded to include chapters covering conceptual topics. In addition to pooling effect sizes, metaanalysis can also be used to estimate disease frequencies, such as incidence and prevalence. The results of each study can be summarized as counts in a 2by2 table. Using metafor or meta for metaanalysis of proportions. Results seven studies totaling 300 patients were included, of which four evaluated the everlinq tva medical, austin, tex and three employed the ellipsys avenu medical, san juan capistrano, calif systems. Stata 7 graphics has been renamed metan7 and is downloaded as part of the. The goals of metaanalysis may be summarized as follows. Metaanalysis of proportions is a little bit different than other types of metaanalysis it includes studies that. Meta analysis is a statistical technique for combining the results. Metaanalysis of proportions and metaregression were conducted.
For each binary effect measure, the metaanalysis was conducted including and excluding zero total event trials using the inverse variance randomeffects model. Meta analyses have become an essential tool in synthesizing evidence on clinical and epidemiological questions derived from a multitude of similar studies assessing the particular issue. The theory and statistical foundations of metaanalysis continually evolve, providing solutions to many new and challenging problems. These studies have a treatment group arm and a control group. Metaanalysis on proportions statalist the stata forum. This module should be installed from within stata by typing ssc install. Included data from more than 175,000 patients with breast cancer. I have been recearching the available literature for some time now and i am still unsure if i am doing this correctly or not. The meta analysis function of jasp is based on the aforementioned metafor r package. An updated collection from the stata journal, second edition, which brought together all the stata journal articles about the. A distinctive and frequently overlooked advantage of binary data is that individual patient data can be extracted.
I have a question regarding meta analysis on pooled proportions e. I am using metaprop to meta analyse proportions from 8 studies using a random effects approach. The outcome of interest in each study is represented by a proportionpercentage. Stata has dialog boxes that can assist you in calculating effect sizes. Additionally, intervention effect estimates with corresponding standard errors or confidence intervals may be metaanalysed. Inclusion of zero total event trials in metaanalyses. I want to do a proportion metaanalysis by taking the proportion of outcome a from the intervention x and the proportion of outcome a from the intervention y and pooling these proportions between. Stata module to perform fixed and random effects meta. Contribute to wnk4242metaprops development by creating an account on github. In practice, most metaanalyses are performed in general statistical packages or dedicated metaanalysis programs. Metaregression models can be used to analyse associations between treatment effect and study characteristics. Stata module to perform fixed and random effects metaanalysis of proportions, statistical software components s457781, boston college department of economics, revised 15 apr 2020. On this page, you can download both the code and the dataset i used in the video. Metaanalysis is increasingly used as a key source of evidence synthesis to inform clinical practice.